个人简介

肖娟，1985生，女，博士/博士后，美狮贵宾会2017年D类高层次人才，美狮贵宾会教授，博士、硕士研究生导师，海南自由贸易港D类人才、南海名家青年、2022、2023年海南省“三区”科技人才。南海特色生物资源开发与利用团队负责人。

教育背景

1）2009.9-2013.12：华中农业大学，食品科技公司，食品科学专业，博士学位。
2）2007.9-2009.6： 华中农业大学，食品科技公司，食品科学专业，硕士学位。
3）2003.9-2007.6： 华中农业大学，水产公司，水产养殖专业，学士学位。

工作经历

1）2023.2 -至今，  美狮贵宾会，教授
2）2017.9-2023.1， 美狮贵宾会，美狮贵宾会D类高层次引进人才、副教授。
3）2014.11-2017.6，广东省农业科公司蚕业与农产品加工研究所，华南农业大学，联合培养博士后。
4）2014.1-2014.10，广东省农业科公司蚕业与农产品加工研究所，研究助理。

科研项目

1)国家自然科学基金地区项目，32360578，植物乳杆菌发酵对琼枝麒麟菜多酚结构特征与生物利用率的影响及机制，2024/01-2027/12，32万元，在研，主持。
2)农业农村部科研项目，RZ2500001204豹纹鳃棘鲈早期营养生理学研究及育苗示范-营养生理学研究，2024/12-2026/12，106万元，在研，主持。
3)横向合作项目，文昌市京基智农时代有限公司污染事件生态环境损害鉴定评估项目，2023/12/20-2024/12/19，8万，已结题，主持。
4)海南省重点研发计划项目，海南主要养殖海藻琼枝的综合利用及产品加工技术研究，2021/9/20-2023/9/19，50万，已结题，主持。
5)国家自然科学基金地区项目，乳酸菌发酵对荔枝果肉酚类物质构成谱、生物可及性的影响及机制，2020/01-2023/12，40万元，已结题，主持。
6)海南省自然科学基金高层次人才项目，乳酸菌发酵对海南特色匍枝马尾藻酚类物质构成谱、健康效应的影响，2020/12/26—2023/12/25，7万，已结题，主持。
7)横向合作项目，万宁东星斑养殖融合发展基地生态环境保护相关报告技术咨询服务和养殖尾水处理工程建造，2020/09-2021/12，65万，到账39万元，已结题，，主持。
8)横向合作项目，《海南分界洲岛违建码头拆除咨询报告》编制，RH2100004742，2021/7/5-2.2022/7/5，29.6万，到账29.6万，已结题，主持。
9)2020年海南省重点研发计划项目，松涛水库饮用水和水产品生物安全风险评估，2020/11/26-2022/11/25，60万，合作单位负责人，占经费36万，已结题。
10)美狮贵宾会引进人才科研启动基金项目，基于miRNA-494调控线粒体功能的荔枝果肉酚类物质改善酒精性肝损伤机制研究，2018/01-2021/12，100万元，已结题，主持。
11)国家自然科学基金青年项目，全谷物糙米主效酚类成分群基于肠道FXR调节脂质代谢作用机制，2016/01-2018/12，22.8万元，已结题，主持。
12)广东省自然科学基金-博士科研启动项目，荔枝果肉多酚对酒精性肝损伤的保护作用及其分子机制，2015/01-2018/01，10万元，已结题，主持。
13)中国博士后科学基金（第59批）一等面上项目，基于线粒体保护的荔枝果肉多酚对酒精性脂肪肝的机制，2016/04-2017/05，8万元，已结题，主持。

文章著作

1.Hui Yu, Meiting Xian, Caiye Qu, Pai Peng, Edwine Yongo, Guanghua Xia, Juan Xiao*, Zhiqiang Guo*, Comprehensive distribution of Se in yellowfin tuna dark meat and characterization of its Se-enriched water-soluble protein, Food Chemistry, 2025, 493(1), 145700, https://doi.org/10.1016/j.foodchem.2025.145700.
2.Pai Peng†, Hui Yu†, Meiting Xian, Caiye Qu, Zhiqiang Guo, Shuyi Li, Zhenzhou Zhu, Juan Xiao*, Preparation of Acetylcholinesterase Inhibitory Peptides from yellowfin Tuna Pancreas Using Moderate Ultrasound-Assisted Enzymatic Hydrolysis. Marine Drugs 2025, 23, 75. https://doi.org/10.3390/md23020075
3.Ziting Peng, Yujiao Wu, Qiongyao Fu*, Juan Xiao*. Free and bound phenolic profiles and antioxidant ability of eleven marine macroalgae from the South China sea. Frontiers in Nutrition. 2024, 11:1459757. doi: 10.3389/fnut.2024.1459757
4.吴耀刚，何雨珂，赵洲，余慧，郭志强，肖娟*. 南海黄鳍金枪鱼不同副产物营养成分及脂肪酸组成分析.食品工业科技, 2024, 1-9.
5.Hui Yu, Meiting Xian, Caiye Qu, Pai Peng, Edwine Yongo, Zhiqiang Guo, Zhixun Du, Juan Xiao*. Novel Se-enriched α-glucosidase inhibitory peptide derived from tuna dark meat: Preparation, identification and effects on IR-HepG2 cells . Food Bioscience, 2024, 60: 104357.  
6.Yuke He, Zhou Zhao, Yaogang Wu, Zhiyuan Lu, Caibo Zhao, Juan Xiao*,  Zhiqiang Guo. Effects of Quality Enhancement of Frozen Tuna Fillets Usingm Ultrasound-Assisted Salting: Physicochemical Properties, Histology, and Proteomics. Foods 2024, 13, 525. https://doi.org/10.3390/foods 13040525.
7.Yuxi Wang, Heqi Gao, Zhiqiang Guo, Ziting Peng, Shuyi Li, Zhenzhou Zhu, Nabil Grimi, Juan Xiao*. Free and Bound Phenolic Profiles and Antioxidant Activities in Melon (Cucumis melo L.) Pulp: Comparative Study on Six Widely Consumed Varieties Planted in Hainan Province. Foods 2023, 12, 4446. https://doi.org/10.3390/foods12244446.
8.Ziting Peng, Yuke He, Zhiqiang Guo, Qian Wu, Shuyi Li, Zhenzhou Zhu, Nabil Grimi, Juan Xiao*. Species-specific arsenic species and health risk assessment in seaweeds from tropic coasts of South China Sea. Ecotoxicology and Environmental Safety 267 (2023) 115634.  
9.Zhe Wang, Caibo Zhao, Zhiqiang Guo, Shuyi Li, Zhenzhou Zhu, Nabil Grimi, Juan Xiao*. Fermentation of Betaphycus gelatinum Using Lactobacillus brevis: Growth of Probiotics, Total Polyphenol Content, Polyphenol Profile, and Antioxidant Capacity. Foods 2023, 12, 3334. https://doi.org/10.3390/foods12183334
10.何雨珂，彭紫亭，赵洲，吴耀刚，郭志强，肖娟*.金枪鱼加工利用研究进展.食品工业，2023，44（12）279-285.
11.王哲, 赵彩博, 肖娟*. 超声波辅助盐酸水解提取琼枝麒麟菜卡拉胶工艺优化. 美狮贵宾会学报(自然科学版). 2023, 1-11. http://kns.cnki.net/kcms/detail/46.1013.N.20230517.1851.008.html.
12.Heqi Gao, Yuxi Wang, Zhiqiang Guo, Yuxin Liu, Qian Wu, and Juan Xiao*. Optimization of ultrasound-assisted extraction of phenolics from Asparagopsis taxiformis with deep eutectic solvent and their characterization by ultra-high-performance liquid chromatography-mass spectrometry. Front. Nutr. 9:1036436. doi: 10.3389/fnut.2022.1036436
13.Haicui Suo, ZitingPeng, Zhiqiang Guo, Chengjunhong Wu, Jitao Liu, Li Wang, Juan Xiao*, Xiaobo Li*. Deep eutectic solvent-based ultrasonic-assisted extraction of phenolic compounds from different potato genotypes: Comparison of free and bound phenolic profiles and antioxidant activity. Food Chemistry, 388 (2022) 133058. https://doi.org/10.1016/j.foodchem.2022.133058.
14.Yuxin Liu, Wang Zhe, Ruifen Zhang, Ziting Peng, Yuxi Wang, Heqi Gao, Zhiqiang Guo, Juan Xiao*. Ultrasonic-assisted extraction of polyphenolic compounds from Paederia scandens (Lour.) Merr. Using deep eutectic solvent: optimization, identification, and comparison with traditional methods. Ultrasonics Sonochemistry 86 (2022) 106005. https://doi.org/10.1016/j.ultsonch.2022.106005.  
15.Ziting Peng, Zhiqiang Guo, Zhe Wang, Ruifen Zhang, Qian Wu, Heqi Gao, Yuxi Wang, Zhixin Shen, Sovan Lek, Juan Xiao*. Species-specific bioaccumulation and health risk assessment of heavy metal in seaweeds in tropic coasts of South China Sea. Science of the Total Environment. 2022, 155031. https://doi.org/10.1016/j.scitotenv.2022.155031
16.Yujiao Wu, Heqi Gao, Yuxi Wang, Ziting Peng, Zhiqiang Guo, Yongxuan Ma, Ruifen Zhang, Mingwei Zhang, Qian Wu, Juan Xiao*, Qiuping Zhong*. Effects of different extraction methods on contents, profiles, and antioxidant abilities of free and bound phenolics of Sargassum polycystum from the South China Sea. Journal of Food Science. 2022, 1-14. DOI: 10.1111/1750-3841.16051
17.Xuerong Song, Hengzhen Ye, Fangfang Jin, Huiying Li, Yang-Su Kim, Juan Xiao*, Zhiqiang Guo*, Effects of fermented soybean meal and guanosine 5′-monophosphate on growth, intestinal health and anti-stress capability of Penaeus vannamei in low fish meal diet, aquaculture. Aquaculture, 2022, 548,737591. https://doi.org/10.1016/ j.aquaculture.2021.737591
18.Nianjie Feng, Yang Shen, Chuanqin Hu, Jiangying Tan, Zhao Huang, Chao Wang,Zhiqiang Guo, Qian Wu*, Juan Xiao*, Inhibition of advanced glycation end products in yogurt by lotus seedpod oligomeric procyanidin.  Frontiers in Nutrition, 2021, 8, 781998. DOI: 10.3389/fnut.2021.781998
19.Nianjie Feng, Shaowen She, Hengfeng Hu, Shimiao Tang, Jiangying Tan, Qian Wu*, Juan Xiao*. Effects of oligomeric procyanidins from lotus seedpod on the retrogradation properties of rice starch. Frontiers in Nutrition, 2021, 8, 751627. DOI:: 10.3389/fnut.2021.751627
20.Juan Xiao, Chengjunhong Wu, Yangeng He, Mengyun Guo, Ziting Peng, Yuxin Liu, Lei Liu, Lihong Dong, Zhiqiang Guo, Ruifen Zhang*, and Mingwei Zhang*. Rice Bran Phenolic Extract Confers Protective Effects against Alcoholic Liver Disease in Mice by Alleviating Mitochondrial Dysfunction via the PGC-1α-TFAM Pathway Mediated by microRNA-494-3p. Journal of Agricultural and Food Chemistry, 2020, 68, 44, 12284-12294. https://dx.doi.org/10.1021/acs.jafc.0c04539.
21.Juan Xiao, Yujiao Wu, Chengjunhong Wu, Xuchao Jia, Lihong Dong, Lei Liu, Yanxia Chen, Yajuan Bai, and Mingwei Zhang*. Rice bran phenolic extract protects against alcoholic liver injury in mice by alleviating intestinal microbiota dysbiosis, barrier dysfunction and liver inflammation mediated by endotoxin-TLR4-NF-κB pathway. Journal of Agricultural and Food Chemistry, 2020, 68, 5, 1237-1247.
22.Juan Xiao, Ruifen Zhang, Qiuyun Zhou, Fei Huang, Lei Liu, Yuanyuan Deng, Zhencheng Wei, Mingwei Zhang*. Lychee (Litchi chinensis Sonn.) pulp phenolic extract provides protection against alcoholic liver injury in mice by alleviating intestinal microbiota dysbiosis, intestinal barrier dysfunction and liver inflammation. Journal of Agricultural and Food Chemistry, 2017, 65 (44), 9675–9684.
23.Juan Xiao, Ruifen Zhang, Fei Huang, Lei Liu, Yuanyuan Deng, Zhencheng Wei, Yan Zhang, Mingwei Zhang*. Lychee (Litchi chinensis Sonn.) pulp phenolic extract confers a protective activity against alcoholic liver disease in mice by alleviating mitochondrial dysfunction. Journal of Agricultural and Food Chemistry, 2017, 65 (24)：5000–5009.
24.Juan Xiao, Ruifen Zhang, Fei Huang, Lei Liu, Yuanyuan Deng, Zhencheng Wei, Yan Zhang, Dong Liu*, Mingwei Zhang*. Biphasic dose effect of Lychee (Litchi chinensis Sonn.) pulp phenolic extract on alcoholic liver disease in mice. Food& Function. 2017, 81(1): 189-200.
25.肖娟，张瑞芬，温叶杰，黄菲，张名位，孙远明*.膳食多酚通过法呢醇X受体调节脂质代谢作用研究进展.食品科学，2017，38(7): 278-283.

获奖

神农中华农业科技奖，农业部（2017）（第7完成人）

专利

1)肖娟，高鹤旗，王玉玺，郭志强，一种海门冬多酚的深共熔溶剂耦合超声辅助提取工艺及其应用，发明专利，中国，专利号：ZL202110964349.7。（已授权)
2)肖娟，冼美婷，郭志强，一种抗氧化富硒肽及超声辅助酶解的制备方法，专利申请号：202510036473.5。
3)肖娟，余慧，郭志强，一种降血糖富硒肽及其制备方法和应用，专利申请号：202410218280.7。
4)肖娟，吴耀刚，郭志强，一种利用金枪鱼鱼头制备金枪鱼鱼油的方法，专利申请号：202410645714.1。
5)肖娟，屈彩烨，郭志强，一种利用黄鳍金枪鱼暗色肉发酵生产低盐优质鱼露的方法，专利申请号202510053170.4。
6)肖娟，赵彩博，郭志强，一种乳酸菌发酵琼枝麒麟菜海藻饮料及其制备方法，专利申请号：202410753855.5。
7)肖娟，李金珍，郭志强，一种多菌种协同发酵的琼枝麒麟菜泡菜及其制备方法，专利申请号202411468810.X。
8)肖娟，武煜姣，郭志强，钟秋平，一种匍枝马尾藻酚类物质提取方法及应用，专利申请号：202210110697.3。
9)肖娟，刘雨欣，郭志强，一种鸡屎藤酚类物质的提取方法及其应用，专利申请号：202110964348.2。

承担教学

(1)本科生课程：《食品安全学》

公司产品

目前在读博士研究生3人、硕士研究生8人，毕业研究生10人，欢迎对南海特色生物资源开发与利用领域感兴趣的同学报考我的研究生。